HDAC7 - SIRT1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
HDAC7	ENSG00000061273	No diseases in record	BELINOSTAT PANOBINOSTAT ROMIDEPSIN	chromatin binding transcription corepressor activity protein kinase C binding protein binding SUMO transferase activity protein kinase binding NAD-dependent histone deacetylase activity (H3-K14 specific) activating transcription factor binding metal ion binding repressing transcription factor binding 14-3-3 protein binding	HDA1 (S. cerevisiae) hda-4 (C. elegans) HDAC4 (D. melanogaster)
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)