SIRT1 - MUS81

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)
MUS81	ENSG00000172732	No diseases in record	No drugs in record	DNA binding endodeoxyribonuclease activity protein binding metal ion binding 3'-flap endonuclease activity crossover junction endodeoxyribonuclease activity nuclease activity endonuclease activity enzyme inhibitor activity hydrolase activity	MUS81 (S. cerevisiae) mus81 (D. melanogaster)