SPO11 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SPO11	ENSG00000054796	No diseases in record	No drugs in record	DNA binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein binding ATP binding endodeoxyribonuclease activity, producing 3'-phosphomonoesters metal ion binding isomerase activity catalytic activity chromatin binding hydrolase activity	mei-W68 (D. melanogaster)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)