KDM4A - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
KDM4A	ENSG00000066135	No diseases in record	No drugs in record	double-stranded DNA binding protein binding zinc ion binding ubiquitin protein ligase binding histone demethylase activity methylated histone binding histone demethylase activity (H3-K36 specific) histone demethylase activity (H3-K9 specific)	GIS1 (S. cerevisiae) RPH1 (S. cerevisiae) jmjd-2 (C. elegans)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)