DOT1L - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
DOT1L	ENSG00000104885	No diseases in record	No drugs in record	DNA binding protein binding histone-lysine N-methyltransferase activity histone methyltransferase activity (H3-K79 specific) histone methyltransferase activity	DOT1 (S. cerevisiae) gpp (D. melanogaster)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)