SHMT2 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SHMT2	ENSG00000182199	No diseases in record	No drugs in record	chromatin binding glycine hydroxymethyltransferase activity protein binding L-allo-threonine aldolase activity amino acid binding pyridoxal phosphate binding identical protein binding	SHM1 (S. cerevisiae) SHM2 (S. cerevisiae)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)