CASP8 - SMAD6

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
CASP8	ENSG00000064012	hepatocellular oral squamous cell breast	No drugs in record	cysteine-type endopeptidase activity death receptor binding tumor necrosis factor receptor binding protein binding peptidase activity cysteine-type peptidase activity ubiquitin protein ligase binding protein complex binding death effector domain binding identical protein binding scaffold protein binding cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Dredd (D. melanogaster)
SMAD6	ENSG00000137834	No diseases in record	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding transcription regulatory region DNA binding metal ion binding co-SMAD binding I-SMAD binding R-SMAD binding type I activin receptor binding	daf-14 (C. elegans) daf-8 (C. elegans) Dad (D. melanogaster)