DOT1L - ERBB2

H. sapiens

SSL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
DOT1L ENSG00000104885

No diseases in record

No drugs in record

DNA binding
protein binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K79 specific)
histone methyltransferase activity
DOT1 (S. cerevisiae)
gpp (D. melanogaster)
ERBB2 ENSG00000141736 breast
ovarian
other tumour types
NSCLC
gastric
AFATINIB
LAPATINIB
PERTUZUMAB
TRASTUZUMAB
TRASTUZUMAB EMTANSINE
VANDETANIB
RNA polymerase I core binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
signal transducer, downstream of receptor, with protein tyrosine kinase activity
transmembrane signaling receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
protein C-terminus binding
protein phosphatase binding
identical protein binding
ErbB-3 class receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
protein dimerization activity
growth factor binding
let-23 (C. elegans)
Egfr (D. melanogaster)