MSH2 - NSD1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MSH2	ENSG00000095002	colorectal endometrial ovarian	No drugs in record	Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding DNA binding protein binding protein C-terminus binding centromeric DNA binding enzyme binding protein kinase binding guanine/thymine mispair binding protein homodimerization activity magnesium ion binding four-way junction DNA binding double-stranded DNA binding single-stranded DNA binding ATP binding ATPase activity mismatched DNA binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding ADP binding nucleotide binding DNA insertion or deletion binding single base insertion or deletion binding damaged DNA binding	MSH2 (S. cerevisiae) spel1 (D. melanogaster)
NSD1	ENSG00000165671	AML	No drugs in record	RNA polymerase II core promoter sequence-specific DNA binding chromatin binding transcription cofactor activity transcription corepressor activity zinc ion binding histone-lysine N-methyltransferase activity estrogen receptor binding histone methyltransferase activity (H4-K20 specific) retinoic acid receptor binding retinoid X receptor binding thyroid hormone receptor binding histone methyltransferase activity (H3-K36 specific) androgen receptor binding	SET2 (S. cerevisiae)