MLH1 - TP53

H. sapiens

SDL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MLH1	ENSG00000076242	colorectal endometrial ovarian CNS tumours CNS	No drugs in record	chromatin binding protein binding ATP binding ATPase activity guanine/thymine mispair binding single-stranded DNA binding MutSalpha complex binding mismatched DNA binding heteroduplex DNA loop binding DNA insertion or deletion binding dinucleotide insertion or deletion binding double-stranded DNA binding DNA binding	MLH1 (S. cerevisiae) Mlh1 (D. melanogaster)
TP53	ENSG00000141510	breast colorectal lung sarcoma adrenocortical glioma Spitzoid tumour multiple other tumour types adrenocortical carcinoma	No drugs in record	RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protease binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding copper ion binding protein binding ATP binding transcription factor binding zinc ion binding enzyme binding protein kinase binding protein phosphatase binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone acetyltransferase binding identical protein binding sequence-specific DNA binding protein self-association transcription regulatory region DNA binding protein heterodimerization activity protein N-terminus binding chaperone binding protein phosphatase 2A binding	No GO terms in record