EP300 - POLE

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
EP300	ENSG00000100393	colorectal breast pancreatic AML ALL DLBCL	No drugs in record	RNA polymerase II core promoter sequence-specific DNA binding core promoter binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding chromatin binding damaged DNA binding transcription coactivator activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor protein binding beta-catenin binding protein C-terminus binding transcription factor binding zinc ion binding acetyltransferase activity transferase activity, transferring acyl groups chromatin DNA binding activating transcription factor binding peptide N-acetyltransferase activity nuclear hormone receptor binding androgen receptor binding pre-mRNA intronic binding	BDF1 (S. cerevisiae) BDF2 (S. cerevisiae) nej (D. melanogaster)
POLE	ENSG00000177084	colorectal carcinoma endometrioid carcinoma stomach carcinoma skin cancer colorectal cancer susceptibility	CLOFARABINE CYTARABINE FLUDARABINE PHOSPHATE GEMCITABINE	nucleotide binding DNA binding chromatin binding DNA-directed DNA polymerase activity zinc ion binding single-stranded DNA 3'-5' exodeoxyribonuclease activity 4 iron, 4 sulfur cluster binding	POL2 (S. cerevisiae) pole-1 (C. elegans) DNApol-epsilon255 (D. melanogaster)