MSH2 - EP300

H. sapiens

SDL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MSH2	ENSG00000095002	colorectal endometrial ovarian	No drugs in record	Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding DNA binding protein binding protein C-terminus binding centromeric DNA binding enzyme binding protein kinase binding guanine/thymine mispair binding protein homodimerization activity magnesium ion binding four-way junction DNA binding double-stranded DNA binding single-stranded DNA binding ATP binding ATPase activity mismatched DNA binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding ADP binding nucleotide binding DNA insertion or deletion binding single base insertion or deletion binding damaged DNA binding	MSH2 (S. cerevisiae) spel1 (D. melanogaster)
EP300	ENSG00000100393	colorectal breast pancreatic AML ALL DLBCL	No drugs in record	RNA polymerase II core promoter sequence-specific DNA binding core promoter binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding chromatin binding damaged DNA binding transcription coactivator activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor protein binding beta-catenin binding protein C-terminus binding transcription factor binding zinc ion binding acetyltransferase activity transferase activity, transferring acyl groups chromatin DNA binding activating transcription factor binding peptide N-acetyltransferase activity nuclear hormone receptor binding androgen receptor binding pre-mRNA intronic binding	BDF1 (S. cerevisiae) BDF2 (S. cerevisiae) nej (D. melanogaster)