TCF7 - PTPN11

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TCF7	ENSG00000081059	No diseases in record	No drugs in record	core promoter binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding beta-catenin binding sequence-specific DNA binding transcription regulatory region DNA binding	pop-1 (C. elegans) pan (D. melanogaster)
PTPN11	ENSG00000179295	JMML AML MDS	No drugs in record	phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity SH3/SH2 adaptor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein domain specific binding receptor tyrosine kinase binding D1 dopamine receptor binding phospholipase binding insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding peptide hormone receptor binding	PTP1 (S. cerevisiae) ptp-2 (C. elegans) csw (D. melanogaster)