ERBB2 - NR4A2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
ERBB2	ENSG00000141736	breast ovarian other tumour types NSCLC gastric	AFATINIB LAPATINIB PERTUZUMAB TRASTUZUMAB TRASTUZUMAB EMTANSINE VANDETANIB	RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity growth factor binding	let-23 (C. elegans) Egfr (D. melanogaster)
NR4A2	ENSG00000153234	No diseases in record	No drugs in record	RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding beta-catenin binding zinc ion binding glucocorticoid receptor binding protein homodimerization activity retinoid X receptor binding protein heterodimerization activity	nhr-6 (C. elegans) Hr38 (D. melanogaster)