PRMT5 - ERCC2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PRMT5	ENSG00000100462	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding transcription corepressor activity protein binding methyltransferase activity methyl-CpG binding histone-arginine N-methyltransferase activity protein-arginine N-methyltransferase activity protein complex binding protein-arginine omega-N symmetric methyltransferase activity ribonucleoprotein complex binding histone methyltransferase activity (H4-R3 specific) protein heterodimerization activity	HSL7 (S. cerevisiae) prmt-5 (C. elegans) csul (D. melanogaster)
ERCC2	ENSG00000104884	skin basal cell skin squamous cell melanoma	No drugs in record	DNA binding ATP-dependent DNA helicase activity protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity 5'-3' DNA helicase activity metal ion binding protein N-terminus binding 4 iron, 4 sulfur cluster binding protein kinase activity RNA polymerase II carboxy-terminal domain kinase activity	RAD3 (S. cerevisiae) Y50D7A.11 (C. elegans) Xpd (D. melanogaster)