SPO11 - GRB2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SPO11	ENSG00000054796	No diseases in record	No drugs in record	DNA binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein binding ATP binding endodeoxyribonuclease activity, producing 3'-phosphomonoesters metal ion binding isomerase activity catalytic activity chromatin binding hydrolase activity	mei-W68 (D. melanogaster)
GRB2	ENSG00000177885	No diseases in record	No drugs in record	phosphotyrosine residue binding SH3/SH2 adaptor activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding neurotrophin TRKA receptor binding protein binding 1-phosphatidylinositol-3-kinase activity SH3 domain binding protein kinase binding protein phosphatase binding identical protein binding insulin receptor substrate binding ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	sem-5 (C. elegans)