Gene Name
|
Gene ID
|
Diseases
|
Drugs
|
GO terms
|
Orthologs
|
ABL1
|
ENSG00000097007
|
CML
ALL
T-ALL
|
BOSUTINIB
DASATINIB
IMATINIB
NILOTINIB
PONATINIB
REGORAFENIB
|
magnesium ion binding
DNA binding
actin monomer binding
nicotinate-nucleotide adenylyltransferase activity
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein kinase C binding
protein binding
ATP binding
protein C-terminus binding
SH3 domain binding
syntaxin binding
manganese ion binding
actin filament binding
mitogen-activated protein kinase binding
proline-rich region binding
receptor binding
|
abl-1 (C. elegans)
Abl (D. melanogaster)
|
LEF1
|
ENSG00000138795
|
B-ALL
T-ALL
eyelid sebaceous carcinoma
AML
lymphomas
|
No drugs in record
|
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
beta-catenin binding
transcription factor binding
DNA binding, bending
estrogen receptor activity
estrogen receptor binding
enhancer binding
histone binding
histone deacetylase binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding
C2H2 zinc finger domain binding
|
pop-1 (C. elegans)
pan (D. melanogaster)
|