CDK8 - TP53

H. sapiens

SDL interaction

 EGFR TP53 KDR MTOR FANCA SOCS3 SUGT1 CYCS GRIP1 NOS3 USP21 LEO1 HGS VAV2 SENP2 ANAPC11 ANAPC2 ITSN1 IRS1 SUZ12 USP32 EPS8 KSR2 ARHGDIA NF2 WEE2 DNAAF2 TCEB1 SAP18 DAB2 RALGDS CDK12 CDK8 EP300 BRCA1 KRAS UBC TOP1 ISG15 ARRB2 CHEK1 BRAF CCNA2 ESR1 SRSF1 CREBBP HIST3H3 FBXW7 MCM7 WRN HNRNPH1 CUL4A UBE2V1 KAT5 CDT1 SMARCC1 FOS SIAH1 HNRNPA1 H2AFX

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
CDK8 ENSG00000132964

No diseases in record

No drugs in record

protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
RNA polymerase II transcription cofactor activity
SSN3 (S. cerevisiae)
cdk-8 (C. elegans)
Cdk8 (D. melanogaster)
TP53 ENSG00000141510 breast
colorectal
lung
sarcoma
adrenocortical
glioma
Spitzoid tumour
multiple other tumour types
adrenocortical carcinoma

No drugs in record

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protease binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
copper ion binding
protein binding
ATP binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
protein phosphatase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
protein heterodimerization activity
protein N-terminus binding
chaperone binding
protein phosphatase 2A binding

No GO terms in record