PIKFYVE - JAK1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PIKFYVE	ENSG00000115020	No diseases in record	No drugs in record	1-phosphatidylinositol-3-phosphate 5-kinase activity protein binding ATP binding zinc ion binding 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	FAB1 (S. cerevisiae) ppk-3 (C. elegans)
JAK1	ENSG00000162434	ALL	RUXOLITINIB TOFACITINIB	protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding protein binding ATP binding protein phosphatase binding ubiquitin protein ligase binding CCR5 chemokine receptor binding metal ion binding	hop (D. melanogaster)