JAK1 - HRAS

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK1	ENSG00000162434	ALL	RUXOLITINIB TOFACITINIB	protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding protein binding ATP binding protein phosphatase binding ubiquitin protein ligase binding CCR5 chemokine receptor binding metal ion binding	hop (D. melanogaster)
HRAS	ENSG00000174775	infrequent sarcomas rare other tumour types rhabdomyosarcoma ganglioneuroblastoma bladder	No drugs in record	GTPase activity protein binding GTP binding protein C-terminus binding	RAS1 (S. cerevisiae) RAS2 (S. cerevisiae) let-60 (C. elegans) Ras85D (D. melanogaster)