TOP2B - ERCC5

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP2B	ENSG00000077097	No diseases in record	ETOPOSIDE TENIPOSIDE	chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding ATP binding protein C-terminus binding DNA binding, bending enzyme binding histone deacetylase binding metal ion binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)
ERCC5	ENSG00000134899	skin basal cell skin squamous cell melanoma	No drugs in record	bubble DNA binding double-stranded DNA binding single-stranded DNA binding endodeoxyribonuclease activity protein binding protein homodimerization activity metal ion binding protein N-terminus binding	RAD2 (S. cerevisiae) xpg-1 (C. elegans)