TOP2B - ERCC3

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP2B	ENSG00000077097	No diseases in record	ETOPOSIDE TENIPOSIDE	chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding ATP binding protein C-terminus binding DNA binding, bending enzyme binding histone deacetylase binding metal ion binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)
ERCC3	ENSG00000163161	skin basal cell skin squamous cell melanoma	No drugs in record	DNA binding damaged DNA binding ATP-dependent DNA helicase activity helicase activity protein binding ATP binding GTP binding protein C-terminus binding transcription factor binding ATPase activity dATP binding peptide binding 3'-5' DNA helicase activity protein N-terminus binding protein kinase activity DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity	SSL2 (S. cerevisiae) xpb-1 (C. elegans) hay (D. melanogaster)