PIAS1 - GRB2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PIAS1	ENSG00000033800	No diseases in record	No drugs in record	DNA binding transcription coactivator activity transcription corepressor activity protein binding protein C-terminus binding transcription factor binding zinc ion binding ligase activity SUMO transferase activity enzyme binding protein domain specific binding ubiquitin protein ligase binding androgen receptor binding SUMO ligase activity	NFI1 (S. cerevisiae) SIZ1 (S. cerevisiae) gei-17 (C. elegans) Su(var)2-10 (D. melanogaster)
GRB2	ENSG00000177885	No diseases in record	No drugs in record	phosphotyrosine residue binding SH3/SH2 adaptor activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding neurotrophin TRKA receptor binding protein binding 1-phosphatidylinositol-3-kinase activity SH3 domain binding protein kinase binding protein phosphatase binding identical protein binding insulin receptor substrate binding ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	sem-5 (C. elegans)