HSP90AB1 - POLE

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
HSP90AB1	ENSG00000096384	NHL	No drugs in record	glycoprotein binding UTP binding CTP binding double-stranded RNA binding protein binding ATP binding GTP binding drug binding sulfonylurea receptor binding protein kinase regulator activity kinase binding protein kinase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding heat shock protein binding dATP binding histone deacetylase binding ion channel binding protein dimerization activity unfolded protein binding cadherin binding involved in cell-cell adhesion histone methyltransferase binding	HSC82 (S. cerevisiae) HSP82 (S. cerevisiae) daf-21 (C. elegans) Hsp83 (D. melanogaster)
POLE	ENSG00000177084	colorectal carcinoma endometrioid carcinoma stomach carcinoma skin cancer colorectal cancer susceptibility	CLOFARABINE CYTARABINE FLUDARABINE PHOSPHATE GEMCITABINE	nucleotide binding DNA binding chromatin binding DNA-directed DNA polymerase activity zinc ion binding single-stranded DNA 3'-5' exodeoxyribonuclease activity 4 iron, 4 sulfur cluster binding	POL2 (S. cerevisiae) pole-1 (C. elegans) DNApol-epsilon255 (D. melanogaster)