SPHK1 - PTPN11

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SPHK1	ENSG00000176170	No diseases in record	No drugs in record	magnesium ion binding DNA binding protein binding calmodulin binding ATP binding sphinganine kinase activity D-erythro-sphingosine kinase activity sphingosine-1-phosphate receptor activity protein phosphatase 2A binding	LCB4 (S. cerevisiae) LCB5 (S. cerevisiae)
PTPN11	ENSG00000179295	JMML AML MDS	No drugs in record	phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity SH3/SH2 adaptor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein domain specific binding receptor tyrosine kinase binding D1 dopamine receptor binding phospholipase binding insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding peptide hormone receptor binding	PTP1 (S. cerevisiae) ptp-2 (C. elegans) csw (D. melanogaster)