POLA1 - PTPN11

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
POLA1	ENSG00000101868	No diseases in record	CLOFARABINE CYTARABINE FLUDARABINE PHOSPHATE GEMCITABINE NELARABINE	nucleotide binding nucleoside binding DNA binding chromatin binding DNA-directed DNA polymerase activity protein binding 3'-5' exonuclease activity protein kinase binding metal ion binding protein heterodimerization activity 4 iron, 4 sulfur cluster binding DNA primase activity	POL1 (S. cerevisiae) DNApol-alpha180 (D. melanogaster)
PTPN11	ENSG00000179295	JMML AML MDS	No drugs in record	phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity SH3/SH2 adaptor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein domain specific binding receptor tyrosine kinase binding D1 dopamine receptor binding phospholipase binding insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding peptide hormone receptor binding	PTP1 (S. cerevisiae) ptp-2 (C. elegans) csw (D. melanogaster)