RUNX2 - ERBB4

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
RUNX2	ENSG00000124813	No diseases in record	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding ATP binding protein domain specific binding bHLH transcription factor binding repressing transcription factor binding	rnt-1 (C. elegans) run (D. melanogaster) lz (D. melanogaster)
ERBB4	ENSG00000178568	melanoma gastric NSCLC	AFATINIB VANDETANIB	protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding protein binding ATP binding protein homodimerization activity transcription regulatory region DNA binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	let-23 (C. elegans) Egfr (D. melanogaster)