POLE - BCR

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
POLE	ENSG00000177084	colorectal carcinoma endometrioid carcinoma stomach carcinoma skin cancer colorectal cancer susceptibility	CLOFARABINE CYTARABINE FLUDARABINE PHOSPHATE GEMCITABINE	nucleotide binding DNA binding chromatin binding DNA-directed DNA polymerase activity zinc ion binding single-stranded DNA 3'-5' exodeoxyribonuclease activity 4 iron, 4 sulfur cluster binding	POL2 (S. cerevisiae) pole-1 (C. elegans) DNApol-epsilon255 (D. melanogaster)
BCR	ENSG00000186716	CML ALL AML	PONATINIB	protein serine/threonine kinase activity protein tyrosine kinase activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding ATP binding kinase activity enzyme binding	BEM2 (S. cerevisiae)