PTPN11 - TCF4

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PTPN11	ENSG00000179295	JMML AML MDS	No drugs in record	phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity SH3/SH2 adaptor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein domain specific binding receptor tyrosine kinase binding D1 dopamine receptor binding phospholipase binding insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding peptide hormone receptor binding	PTP1 (S. cerevisiae) ptp-2 (C. elegans) csw (D. melanogaster)
TCF4	ENSG00000196628	No diseases in record	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, TFIIB-class binding TFIIB-class transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein C-terminus binding identical protein binding protein homodimerization activity bHLH transcription factor binding protein heterodimerization activity E-box binding	hlh-2 (C. elegans)