ERCC4 - POLE

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
ERCC4	ENSG00000175595	skin basal cell skin squamous cell melanoma	No drugs in record	single-stranded DNA endodeoxyribonuclease activity TFIID-class transcription factor binding damaged DNA binding single-stranded DNA binding endodeoxyribonuclease activity protein binding protein C-terminus binding protein N-terminus binding	RAD1 (S. cerevisiae) xpf-1 (C. elegans) mei-9 (D. melanogaster)
POLE	ENSG00000177084	colorectal carcinoma endometrioid carcinoma stomach carcinoma skin cancer colorectal cancer susceptibility	CLOFARABINE CYTARABINE FLUDARABINE PHOSPHATE GEMCITABINE	nucleotide binding DNA binding chromatin binding DNA-directed DNA polymerase activity zinc ion binding single-stranded DNA 3'-5' exodeoxyribonuclease activity 4 iron, 4 sulfur cluster binding	POL2 (S. cerevisiae) pole-1 (C. elegans) DNApol-epsilon255 (D. melanogaster)