UPF1 - MRE11

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
UPF1	ENSG00000005007	No diseases in record	No drugs in record	chromatin binding RNA binding ATP-dependent RNA helicase activity helicase activity protein binding ATP binding zinc ion binding telomeric DNA binding DNA binding	NAM7 (S. cerevisiae) smg-2 (C. elegans) Upf1 (D. melanogaster)
MRE11	ENSG00000020922	No diseases in record	No drugs in record	hydrolase activity exonuclease activity endonuclease activity protein complex scaffold activity manganese ion binding nuclease activity 3'-5' exonuclease activity G-quadruplex DNA binding single-stranded telomeric DNA binding double-stranded telomeric DNA binding telomeric DNA binding endodeoxyribonuclease activity adenylate kinase activity protein binding DNA end binding single-stranded DNA endodeoxyribonuclease activity Y-form DNA binding single-stranded DNA 3'-5' exodeoxyribonuclease activity double-stranded DNA 3'-5' exodeoxyribonuclease activity	MRE11 (S. cerevisiae) mre-11 (C. elegans)