SMAD4 - HDAC3

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SMAD4	ENSG00000141646	colorectal pancreatic small intestine gastrointestinal polyp	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding chromatin binding protein binding collagen binding transforming growth factor beta receptor, common-partner cytoplasmic mediator activity identical protein binding protein homodimerization activity transcription regulatory region DNA binding metal ion binding protein heterodimerization activity I-SMAD binding R-SMAD binding transcription factor activity, protein binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding	Med (D. melanogaster)
HDAC3	ENSG00000171720	No diseases in record	BELINOSTAT PANOBINOSTAT ROMIDEPSIN VORINOSTAT	chromatin binding transcription corepressor activity histone deacetylase activity protein binding transcription factor binding enzyme binding cyclin binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding NF-kappaB binding	RPD3 (S. cerevisiae) Hdac3 (D. melanogaster)