CYC8 - SIR2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
CYC8	YBR112C	No diseases in record	No drugs in record	transcriptional repressor activity, RNA polymerase II transcription factor binding histone deacetylase binding transcriptional activator activity, RNA polymerase II transcription factor binding	KDM6A (H. sapiens) KDM6B (H. sapiens)
SIR2	YDL042C	No diseases in record	No drugs in record	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides NAD-dependent histone deacetylase activity NAD-dependent histone deacetylase activity (H3-K14 specific) hydrolase activity nucleosome binding zinc ion binding NAD binding NAD+ binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K4 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K14 specific)	SIRT1 (H. sapiens)