Slorth is a database of synthetic lethal interaction that are either experimentally verified or are high quality predictions using the state of the art algorithm SLant. SLant works by using synthetic lethal data from human, worm, fly and yeast sources to identify the patterns in the protein-protein interaction network associated with being part of a synthetic lethal interaction. By searching the human network for protein pairs that match these patterns, it can effectively predict new synthetic lethal pairs.
June 6, 2019 - SLant predictions updated based on BioGRID version 3.5.172
April 17, 2019 - Predicting synthetic lethal interactions using conserved patterns in protein interaction networks published in PLOS computational biology